Win-62005
CAS No. : 152633-54-0
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| Cat. No. : | HY-U00136 |
| M.Wt: | 226.23 |
| Formula: | C12H10N4O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Win-62005 is a cyclic AMP phosphodiesterase III (PDE III) inhibitor with Kis of 25 and 26 nM for rat heart and canine aorta, respectively. IC50 & Target: Ki: 25 nM (PDE III), 25 nM (PDE III)[1] In Vitro: Win-62005 competitively inhibits cyclic GMP-inhibitable low Km cyclic AMP phosphodiesterase (PDE III) from rat heart and canine aorta with Ki values of 25±3 and 26±5 nM, respectively and is selective (at least 160-fold) for PDE III inhibition relative to other PDE isozymes[1]. In Vivo: After p.o. administration of 1 mg/kg Win-62005, LVdP/dtmax is significantly increased in 30 min and remains increased for at least 6 h[1].
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