Nebivolol (hydrochloride)
CAS No. : 152520-56-4
(Synonyms: R 065824 hydrochloride)
| Size | Price | Stock |
|---|---|---|
| 5mg | $30 | In-stock |
| 10mg | $45 | In-stock |
| 25mg | $72 | In-stock |
| 50mg | $100 | In-stock |
| 100mg | $160 | In-stock |
| 500mg | $480 | In-stock |
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| Cat. No. : | HY-B0203A |
| M.Wt: | 441.90 |
| Formula: | C22H26ClF2NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 1.79 mg/mL (ultrasonic;warming;heat to 60°C) |
Nebivolol (R 065824) hydrochloride is an orally active beta receptor blocker and has the high beta(1)-receptor affinity.Nebivolol hydrochloride has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol hydrochloride can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease[1][2].
In Vitro: Nebivolol hydrochloride improves endothelial dysfunction via its strong stimulatory effects on the activity of the endothelial nitric oxide synthase and via its antioxidative properties[1].
Nebivolol hydrochloride (0.1 μM-10 μM, 1, 2, 4, 7 or 14 days) inhibits haCSMC or haEC proliferation with IC50 values of ~ 6.0 μM[2].
Nebivolol hydrochloride (0.1 μM-10 μM, 24 h) induces a moderate rate of apoptosis[2].
Nebivolol hydrochloride (0.1, 1, 5,10 μM, 4 days)increases NO formation and decreases endothelin-1 secretion in HaCEs[2]
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