Agelastatin A
CAS No. : 152406-28-5
(Synonyms: (-)-Agelastatin A; AglA)
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| Cat. No. : | HY-125132 |
| M.Wt: | 341.16 |
| Formula: | C12H13BrN4O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Agelastatin A ((-)-Agelastatin A; AglA), a tetracyclic alkaloid isolated from the sponge Agelas dendromorpha, induces apoptosis and arrests cells in the G2/M phase of the cell cycle, exhibiting antitumor activity[1].
In Vitro:Agelastatin A(0-2 μM, 48 h) has IC50 values of 67 nM, 708 nM, 1.05 μM, 278 nM and 1.11 μM on U-937, HeLa, A549, BT549 and IMR90 cells, respectively[1].
Agelastatin A(0-1 μM, 48 h) has IC50 values of 20, 74, 20, 138 and 187 nM on CEM, Jurkat, Daudi, HL-60 and CA46 cells, respectively[1].
Agelastatin A (0-150 nM, 16 h) can dose-dependently induce U-937 cell cycle arrest at G2/M[1].
In Vivo:The pharmacokinetic parameters of Agelastatin A(1a) a single 2.5 mg/kg dose in mice[2].
| Parameter/td> | intravenous (IV) | intraperitoneal (IP) |
| ACU | 1742 | 2946 |
| Cmax | 4.5 μM | 1.65 μM |
| Tmax | 2 min | 30 min |
| t1/2 | 4 min | 1 h |
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