Adezmapimod (Standard)
CAS No. : 152121-47-6
(Synonyms: SB 203580 (Standard); RWJ 64809 (Standard))
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| Cat. No. : | HY-10256R |
| M.Wt: | 377.43 |
| Formula: | C21H16FN3OS |
| Purity: | >98 % |
| Solubility: |
Adezmapimod (Standard) is the analytical standard of Adezmapimod. This product is intended for research and analytical applications. Adezmapimod (SB 203580) is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod can inhibit p38 MAPK and lead to the inhibition of downstream HSP27 phosphorylation. Adezmapimod does not disrupt JNK activity and is an autophagy and mitophagy activator[1][2][3].
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