SB 203580 sulfone
CAS No. : 152121-46-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $192 | In-stock |
| 25mg | $384 | In-stock |
| 50mg | $615 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-112349 |
| M.Wt: | 393.43 |
| Formula: | C21H16FN3O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;warming);DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
SB 203580 sulfone is an analog of p38 MAP kinase inhibitor SB 203580. SB 203580 sulfone inhibits the IL-1 production (IC50 of 0.2 μM in monocytes) and binds competitively with CSAID binding proteins (CSBP), inhibits it mediated stress response signaling with an IC50 of 0.03 μM. SB 203580 sulfone inhibits 5-LO with an IC50 value of 24 µM. SB 203580 sulfone can be used in the research of inflammatory diseases[1][2].
IC50 & Target:IC50: 0.03 μM (CSBP); 24 µM (5-LO)
In Vitro:SB 203580 sulfone (Compound 48) inhibits IL-1 production in monocytes with an IC50 of 0.2 μM[1].
SB 203580 sulfone (Compound 3) inhibits 5-LO with an IC50 value of 24 µM (the assay uses semi-purified enzyme from RBL-1 cells)[2].
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