(S)-Norzopiclone
CAS No. : 151776-26-0
(Synonyms: (S)-N-Desmethyl zopiclone; SEP-174559)
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| Cat. No. : | HY-U00199A |
| M.Wt: | 374.78 |
| Formula: | C16H15ClN6O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
(S)-Norzopiclone ((S)-N-Desmethyl zopiclone; SEP-174559) is a metabolite of Zopiclone with anxiolytic and anticonvulsant effects. (S)-Norzopiclone has benzodiazepine-like actions at γ2-bearing subtypes of the GABAA receptor and inhibits nACh and NMDA receptors[1].
In Vitro: Micromolar concentrations of (S)-Norzopiclone (SEP-174559) potentiates GABAA receptor currents evoked by subsaturating concentrations of GABA[1].
(S)-Norzopiclone9 is not selective between alpha1-, alpha2-, or alpha3-bearing GABAA receptors. Within the nicotinic receptor superfamily, (S)-Norzopiclone does not affect serotonin type-3 receptor function but is found to inhibit nACh receptors[1].
In the glutamate receptor superfamily, (S)-Norzopiclone inhibits N-methyl-D-aspartate (NMDA) receptor currents but does not affect non-NMDA receptors[1].
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