Pironetin
CAS No. : 151519-02-7
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| 1mg | $787 | In-stock |
| 5mg | $2600 | In-stock |
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| Cat. No. : | HY-116446 |
| M.Wt: | 324.45 |
| Formula: | C19H32O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Pironetin is an α/β unsaturated lactone isolated from Streptomyces species. Pironetin binds to α-tubulin and is a potent inhibitor of microtubule polymerization, and has cell cycle arrest and antitumor activity[1][2].
IC50 & Target: Microtubule[1]
In Vitro: Pironetin (20-100 ng/mL; 24 hours; 3Y1 cells) treatment arrests the cell cycle progression at G2/M in 3Y1 cells[1].
Pironetin (1-10000 ng/mL; 3 days; HeLa, A2780 and K-NRK cells) treatment inhibits the cell proliferation. IC50 values against these cell lines are almost 10 ng/mL[1].
In Vivo: Pironetin (0.78-6.25 mg/kg; intraperitoneal injection; daily; for 5 days; female CDF1-SLC mice) treatment shows a moderate antitumor effect, however, a severe weight loss is observed as a side effect[1].
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