(S)-Ro 32-0432 (free base)
CAS No. : 151342-35-7
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| Cat. No. : | HY-108601 |
| M.Wt: | 452.55 |
| Formula: | C28H28N4O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
(S)-Ro 32-0432 free base is a potent, selective, ATP-competitive and orally active PKC inhibitor. The IC50 values of (S)-Ro 32-0432 free base for PKCα, PKCβI, PKCβII, PKCγ and PKCε are 9.3 nM, 28 nM, 30 nM, 36.5 nM and 108.3 nM, respectively. (S)-Ro 32-0432 free base is also a selective G protein-coupled receptor kinase 5 (GRK5) inhibitor. (S)-Ro 32-0432 free base prevents T-cell activation and has the potential for chronic inflammatory and autoimmune diseases research[1][2].
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