S-8921
CAS No. : 151165-96-7
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| Cat. No. : | HY-19298 |
| M.Wt: | 540.60 |
| Formula: | C30H36O9 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
S-8921 is an ileal Na+/bile acid cotransporter (IBAT) inhibitor. IC50 & Target: IBAT[1] In Vitro: S-8921 is an ileal Na+/bile acid cotransporter (IBAT) inhibitor. S-8921 inhibits the uptake velocity of 60 μM [3H] taurocholate dose-dependently in IBAT-COS cells, and the IC50 value of S-8921 is 66±8 μM[1]. In Vivo: Seven-day treatment with S-8921 causes a dramatic decrease of serum cholesterol concentrations in hamsters. The hypocholesterolemic effects of S-8921 are dose-dependent, but S-8921 does not affect body weight. An increase of fecal bile acid excretion is observed especially at higher doses of S-8921[1]. S-8921 treatment for 1 to 2 weeks causes a decrease in serum total cholesterol concentrations, with 0.01% S-8921 (4.0 to 4.6 mg/kg) being almost maximally effective[2].
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