β-Aminopropionitrile
CAS No. : 151-18-8
(Synonyms: BAPN)
| Size | Price | Stock |
|---|---|---|
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| 1g | $88 | In-stock |
| 5g | $281 | In-stock |
| 10g | $420 | In-stock |
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| Cat. No. : | HY-Y1750 |
| M.Wt: | 70.09 |
| Formula: | C3H6N2 |
| Purity: | >98 % |
| Solubility: | H2O : 50 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic) |
β-Aminopropionitrile (BAPN) is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes[1][2].
In Vitro: β-Aminopropionitrile (BAPN) normalizes the expression of GLUT4 and adiponectin, and improves glucose uptake in an in vitro model of insulin resistance[1].
β-Aminopropionitrile (500 μM; 72 h) blocks the hypoxia-induced EMT morphological and marker protein changes, and inhibits invasion and migration capacities of cervical carcinoma cells in vitro[2].
In Vivo: β-Aminopropionitrile (BAPN) (100 mg/kg/day; p.o.; 6 weeks) reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats[1].
β-Aminopropionitrile monofumarate (1 g/kg/day; p.o.; 4 weeks) induces thoracic aortic dissection in C57BL/6 mice[3].
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