Tegafur-gimeracil-oteracil (potassium)
CAS No. : 150863-82-4
(Synonyms: S-1; TS-1)
| Size | Price | Stock |
|---|---|---|
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| 10mg | $175 | In-stock |
| 25mg | $345 | In-stock |
| 50mg | $550 | In-stock |
| 100mg | $880 | In-stock |
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| Cat. No. : | HY-16441 |
| M.Wt: | 540.89 |
| Formula: | C17H15ClFKN6O9 |
| Purity: | >98 % |
| Solubility: | H2O : 5.56 mg/mL (ultrasonic);DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) |
Tegafur-gimeracil-oteracil potassium (S-1; TS-1) is an orally active anticancer agent composed of Tegafur (HY-17400), Gimeracil (HY-17469), and Oteracil potassium (HY-17511). Tegafur-gimeracil-oteracil potassium inhibits the proliferation, migration and invasion of endometrial cancer cells and induces apoptosis by blocking the PI3K/AKT/mTOR signaling pathway. Tegafur-gimeracil-oteracil potassium can be used in research related to endometrial cancer and gastric cancer with peritoneal metastasis[1][2].
In Vitro:Tegafur-gimeracil-oteracil potassium (1-50 μg/mL; 6-48 h) significantly inhibits the viability of Ishikawa and HEC-1-A endometrial cancer cells in a dose- and time-dependent manner, with corresponding IC50 values of 16.26 μg/mL and 11.33 μg/mL for the two cell lines, respectively[1].
Tegafur-gimeracil-oteracil potassium (5-50 μg/mL; 24-72 h) inhibits the proliferation of Ishikawa and HEC-1-A endometrial cancer cells in a concentration-dependent manner[1].
Tegafur-gimeracil-oteracil potassium (5-50 μg/mL) reduces DNA synthesis capacity and proliferative activity of Ishikawa and HEC-1-A endometrial cancer cells in a concentration-dependent manner[1].
Tegafur-gimeracil-oteracil potassium (5-50 μg/mL; 24 h) inhibits the migration of Ishikawa and HEC-1-A endometrial cancer cells in a dose-dependent manner[1].
Tegafur-gimeracil-oteracil potassium (5-50 μg/mL; 24 h) inhibits the invasion of Ishikawa and HEC-1-A endometrial cancer cells in a dose-dependent manner[1].
Tegafur-gimeracil-oteracil potassium (5-50 μg/mL) promotes apoptosis of Ishikawa and HEC-1-A endometrial cancer cells in a concentration-dependent manner[1].
Tegafur-gimeracil-oteracil potassium (10-25 μg/mL) upregulates the mRNA expression of the pro-apoptotic protein Bax and downregulates the mRNA expression of the anti-apoptotic protein Bcl-2 in Ishikawa and HEC-1-A endometrial cancer cells[1].
Tegafur-gimeracil-oteracil potassium (10-25 μg/mL) upregulates the expression of the pro-apoptotic Bax protein and downregulates the expression of the anti-apoptotic Bcl-2 protein in Ishikawa and HEC-1-A endometrial cancer cells[1].
Tegafur-gimeracil-oteracil potassium (25 μg/mL) inhibits the PI3K/AKT/mTOR signaling pathway by reducing the phosphorylation levels of PI3K, AKT and mTOR in Ishikawa and HEC-1-A endometrial cancer cells[1].
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