Gap19
CAS No. : 1507930-57-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $115 | In-stock |
| 10mg | $175 | In-stock |
| 25mg | $285 | In-stock |
| 50mg | $454 | In-stock |
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| Cat. No. : | HY-P1136 |
| M.Wt: | 1161.44 |
| Formula: | C55H96N14O13 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial[1][2].
IC50 & Target: Cx43 Hemichannel[1]
In Vitro: Gap19 (250 μM; for 30 min ) decreases mitochondrial potassium uptake[1].
Gap19 (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells[2].
Gap19 (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes[2].
Gap19 (250 μM, 30 min) protects against myocardial ischemia/reperfusion injury in vitro and in vivo[2].
In Vivo: Gap19 (iv; 25 mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth[2].
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