TAT-Gap19
CAS No. : 1507930-54-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $220 | In-stock |
| 5mg | $620 | In-stock |
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| Cat. No. : | HY-P1136B |
| M.Wt: | 2703.25 |
| Formula: | C119H212N46O26 |
| Purity: | >98 % |
| Solubility: | H2O : 50 mg/mL (ultrasonic);DMSO : 2 mg/mL (ultrasonic) |
TAT-Gap19, a Cx mimetic peptide, is a specific connexin43 hemichannel (Cx43 HC) inhibitor. TAT-Gap19 does not inhibits the corresponding Cx43 GJCs. TAT-Gap19 traverses the blood-brain barrier and alleviate liver fibrosis in mice[1][2][3].
In Vivo: A single injection of TAT-Gap19 (i.v. via the tail vein; 55 mg/kg) produces significant immune signal in the brain 24 h later in 4 months old C57Bl6 male mice[1].
TAT-Gap19 (1 mg/kg/day; an osmotic pump implanted in the peritoneal cavity; Two weeks) shows significantly decreased collagen deposition, as well as lowed amounts of α-SMA-positive cells area in mice subjected to treatment with 100-200 mg thioacetamide (TAA)/kg body weight for eight weeks[2].
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