Tolvaptan
CAS No. : 150683-30-0
(Synonyms: OPC-41061)
| Size | Price | Stock |
|---|---|---|
| 5mg | $92 | In-stock |
| 10mg | $144 | In-stock |
| 25mg | $288 | In-stock |
| 50mg | $465 | In-stock |
| 100mg | $730 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-17000 |
| M.Wt: | 448.94 |
| Formula: | C26H25ClN2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist with an IC50 of 1.28 μM for the inhibition of arginine vasopressin (AVP)-induced platelet aggregation. Tolvaptan induces cell apoposis and affects cell cycle. Tolvaptan can be used for the research of hyponatremia[1][2]. In Vitro: Tolvaptan (0-100 μM; 24-168 h) decreases the growth of HepG2 cells[2]. Tolvaptan (20-100 μM; 24-48 h) induces cell death in HepG2 cells[2]. Tolvaptan (0-100 μM; 24-48 h) affects cell cycle of HepG2 cells[2]. Tolvaptan (0-100 μM; 24-48 h) causes DNA damage and induces apoptosis of HepG2 cells[2]. Tolvaptan (0-100 μM; 24-48 h) decreases cyclins and CDKs, and increases γ-H2AX, PARP cleavage and LC3B-II in HepG2 cells[2]. Tolvaptan (0-100 μM; 4-24 h) induces phosphorylation of JNK, ERK1/2 and p38 in HepG2 cells[2]. Tolvaptan (0-100 μM; 24-28 h) induces autophagy of HepG2 cells[2]. In Vivo: Tolvaptan (10 mg/kg; p.o. once per day for 22 days) improves cyclophosphamide (CP)-induced nephrotoxicity in rats[3].
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