Lactisole
CAS No. : 150436-68-3
| Size | Price | Stock |
|---|---|---|
| 5g | $61 | In-stock |
| 25g | $216 | In-stock |
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| Cat. No. : | HY-W030796A |
| M.Wt: | 218.18 |
| Formula: | C10H11NaO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Lactisole is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole inhibits insulin secretion induced by glucose in mouse islets[1][2].
IC50 & Target:T1R3[1]
In Vitro: Lactisole (3-10 mM; 48 h) does-dependently inhibits insulin secretion induced by Acesulfame-K, Sucralose (HY-N0614) and Glycyrrhizin (HY-N0184) in mouse pancreatic β-cells MIN6 (IC50~4 mM)[1].
Lactisole (5 mM; 48 h) attenuates the elevation of cytoplasmic Ca2+ concentration ([Ca2+]c) evoked by sucralose and acesulfame-K without affecting the elevation of intracellular cAMP concentration ([cAMP]c)[1].
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