Indinavir
CAS No. : 150378-17-9
(Synonyms: MK-639 (free base); L-735524 (free base))
| Size | Price | Stock |
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| 5mg | $197 | In-stock |
| 10mg | $375 | In-stock |
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| Cat. No. : | HY-B0689 |
| M.Wt: | 613.79 |
| Formula: | C36H47N5O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is also a SARS-CoV 3CLpro inhibitor[1][2][3][4].
IC50 & Target:Ki: 0.54 nM (PR), 1.40 nM (PRL24I), 27.0 nM (PRI50V), 0.55 nM (PRG73S)[3].
In Vitro: Indinavir (0-50 μM; 18 h) blocks lymphocyte cell cycle in G0/G1 phase in PBMCs cells and impairs lymphoproliferative responses[1].
Indinavir (40 μM-40 nM; 5 days) inhibits cell invasion and (40 μM-40 nM; 48 h) MMPs-2 activation of the Huh7 and SK-HEP-1 hepatocarcinoma cells in vitro[2].
In Vivo: Indinavir (70 mg/kg; i.g.; once a day for 3 weeks) inhibits the growth of hepatocarcinoma cells in vivo[2].
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