(S)-MCPG
CAS No. : 150145-89-4
(Synonyms: (+)-MCPG)
| Size | Price | Stock |
|---|---|---|
| 5mg | $79 | In-stock |
| 10mg | $106 | In-stock |
| 25mg | $238 | In-stock |
| 50mg | $436 | In-stock |
| 100mg | $871 | In-stock |
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| Cat. No. : | HY-100406 |
| M.Wt: | 209.20 |
| Formula: | C10H11NO4 |
| Purity: | >98 % |
| Solubility: | 1M NaOH : 22 mg/mL (ultrasonic;adjust pH to 11 with NaOH);H2O : 100 mg/mL (ultrasonic;adjust pH to 13 with 1M NaOH) |
(S)-MCPG ((+)-MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS)-MCPG (HY-100371)[1]. (S)-MCPG can be used for the study of the function of mGluRs in spatial learning[2]. In Vitro: (S)-MCPG (100 μM) has no detectable effects on basal spine formation or elimination mechanisms in WT slice cultures. (S)-MCPG prevents the increase in spine turnover triggered by TBS and interferes with the mechanisms of activity-dependent spine stabilization in Hippocampal slice cultures[1]. In Vivo: MCPG (intraventricular injection; 20 μg) treated rat are slower to learn the task and takes longer to reach the platform than vehicle injected animals. On days 2 and 3, MCPG rats has a significant longer escape latency and the measure of search error is significantly longer on each of the first 3 days. On day 4, MCPG-treated animals reaches the same level of performance as control animals in Morris water maze[2].
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