Rimantadine (hydrochloride)
CAS No. : 1501-84-4
| Size | Price | Stock |
|---|---|---|
| 100mg | $66 | In-stock |
| 1g | $80 | In-stock |
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| Cat. No. : | HY-B0338A |
| M.Wt: | 215.76 |
| Formula: | C12H22ClN |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic);H2O : 33.33 mg/mL (ultrasonic) |
Rimantadine hydrochloride (Flumadine hydrochloride) is an orally active inhibitor for M2 protein, that blocks the hydrogen ion channel activity, prevents the entry and replication of the virus, and exhibits board-spectrum antiviral activity[1].
In Vitro:Rimantadine hydrochloride (0-10 μg/mL, 72 h) inhibits the RNA levels of hepatitis A virus (HAV) in Huh7 and IHH cells with IC50 of 6.7 and 1.6 μg/mL[1].
Rimantadine hydrochloride (0-10 μg/mL, 72 h) increases the expression of the autophagy marker LC3, inhibits the phosphorylation of mTOR, increases the number of lysosomes, and promotes autophagy in HAV-infected Huh7 cell[1].
In Vivo:Rimantadine hydrochloride (20-80 mg/kg/day, po for 5 days) exhibits anti-infectious activity with Oseltamivir (HY-13317) in H3N2-infected mouse models[2].
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