UU-T02
CAS No. : 1500080-17-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $240 | In-stock |
| 5mg | $600 | In-stock |
| 10mg | $850 | In-stock |
| 25mg | $1360 | In-stock |
| 50mg | $2050 | In-stock |
| 100mg | $3075 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-117233 |
| M.Wt: | 665.09 |
| Formula: | C33H33ClN4O9 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) with a Ki of 1.36 μM[1]. UU-T02 inhibits canonical Wnt signaling and the growth of colorectal cancer cells[2].
IC50 & Target: Ki: 1.36 μM (β-catenin/Tcf PPI)[1].
IC50: 6.3 μM (β-catenin/Tcf4), 680 μM (β-catenin/E-cadherin) , 210 μM (β-catenin/APC-R3)[2].
In Vitro: UU-T02 displays Ki values of 1.4 μM and 1.3 μM for β-catenin/Tcf PPI in FP assay and in AlphaScreen assay, respectively[2].
UU-T02 inhibits β-catenin/Tcf4, β-catenin/E-cadherin, β-catenin/APC-R3, with the IC50 of 6.3, 680, 210 μM，respectively[2].
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