Azimilide
CAS No. : 149908-53-2
(Synonyms: NE-10064)
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $95 | In-stock |
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| Cat. No. : | HY-18600 |
| M.Wt: | 457.95 |
| Formula: | C23H28ClN5O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Azimilide (NE-10064) is a class III antiarrhythmic agent, which works by blocking potassium channels in the heart. Azimilide is a dual blocker of IKs (IC50 = 2.6 μM (2mM [K⁺]ₑ)) and IKr (IC50 = 1 μM (4 mM [K⁺])). Azimilide blocked HERG channel at 0.1 and 1 Hz with IC50s of 1.4 μM and 5.2 μM respectively. Azimilide also inhibits L-type calcium current (ICa) (IC50 = 17.8 μM) and sodium current (INa) (IC50 = 19 μM). Azimilide can be used for the study of atrial fibrillation and ventricular fibrillation[1][2][3][4].
In Vitro:Azimilide (0.1-100 μM) blocks IKr (reversibly dependent, affected by [K⁺]ₑ) and IKs channels (dependently on use, unaffected by [K⁺]ₑ) in mouse AT-1 cells and African clawed frog oocytes[1].
Azimilide (0.3-5 μM) shortens the action potential duration (APD) of canine and guinea pig ventricular muscle cells[2][3].
In Vivo:Azimilide (10 mg/kg, i.v., single dose) significantly reduces the occurrence of ventricular tachycardia (VT) induced by electrical stimulation (PES) in dogs[4].
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