MDL 101146
CAS No. : 149859-17-6
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| Cat. No. : | HY-117668 |
| M.Wt: | 632.62 |
| Formula: | C29H37F5N4O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a Ki value of 25 nM. MDL 101146 can be used for the research of arthritis[1][2].
IC50 & Target:Ki for neutrophil elastase: 25 nM (human); 18 nM (rat)[1][2]
In Vitro: MDL 101,146 inhibits human neutrophil elastase with a Ki value of 25 nM[1].
MDL 101,146 inhibits rat neutrophil elastase activity in a dose-related manner with a Ki value of 18 nM[2].
In Vivo: MDL 101146 (oral, 200 mg/kg/day) significantly inhibits swelling and joint destruction in collagen-induced arthritis but not in adjuvant arthritis[2].
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