Chrysosplenol D
CAS No. : 14965-20-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $250 | In-stock |
| 10mg | $390 | In-stock |
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| Cat. No. : | HY-N6007 |
| M.Wt: | 360.31 |
| Formula: | C18H16O8 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Chrysosplenol D is a methoxy flavonoid that induces ERK1/2-mediated apoptosis in triple negative human breast cancer cells. Chrysosplenol D also exhibits anti-inflammatory and moderate antitrypanosomal activities[1][2][3][4].
In Vitro: Chrysosplenol D inhibits the cell viability of CaCo2 cells, with IC50 of 63.48 μM[1].
Chrysosplenol D (1-100 μM; 48 h) selectively inhibits the viability of the TNBC cell lines, MDA-MB-231, CAL-51, CAL-148, as well as MCF7, A549, MIA PaCa-2, and PC-3[2].
Chrysosplenol D (1-10 μM; 48 h) induces cell cycle aberrations with accumulation of cells in the S-phase and partially in the G2/M-phase of the cell cycle[2].
Chrysosplenol D (1-10 μM; 48 h) induce apoptosis in breast cancer cells[2].
Chrysosplenol D shows moderate antitrypanosomal activity, with IC50 of 47.27 μM for T.b. brucei[3].
In Vivo: Chrysosplenol D (30 μM; 3 d) inhibits MDA-MB-231 tumor growth on chick chorioallantoic membranes[2].
Chrysosplenol D (0.07-0.28 mmol/kg) protects against LPS-induced systemic inflammatory response syndrome (SIRS) in mice[4].
Chrysosplenol D (1-1.5 μmol/cm2) inhibits croton oil-induced ear edema in mice[4].
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