Cidofovir (dihydrate)
CAS No. : 149394-66-1
(Synonyms: GS 0504 (dihydrate); HPMPC (dihydrate); (S)-HPMPC (dihydrate))
| Size | Price | Stock |
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| 5mg | $41 | Get quote |
| 10mg | $66 | Get quote |
| 50mg | $106 | Get quote |
| 100mg | $172 | Get quote |
| 200 mg | Get quote | |
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| Cat. No. : | HY-17438A |
| M.Wt: | 315.22 |
| Formula: | C8H18N3O8P |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Cidofovir (GS 0504; HPMPC; (S)-HPMPC) dihydrate is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir dihydrate inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir dihydrate induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer[1][3]. Cidofovir dihydrate also has anti-orthopoxvirus and anti-variola activities[4].
In Vitro: Cidofovir (5-100 μM, 72 hours) dihydrate has antiviral activity against feline herpesvirus type-1 (FHV-1) with an IC50 of 11 μM, and can reduce Crandell-Reese feline kidney cells counts in a dose dependent manner[1].
Cidofovir (10-1000 μM, 24-120 hours) dihydrate can reduce cancer cell viability and induces apoptosis[3].
In Vivo: Cidofovir (subcutaneous injection, 100 mg/kg, 3-6 days interval, 21 days) dihydrate is highly protective against death from cowpox virus (CPV) infection at high doses in female weanling BALB/c mice[2].
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