BM635
CAS No. : 1493762-74-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $65 | In-stock |
| 10mg | $105 | In-stock |
| 25mg | $210 | In-stock |
| 50mg | $340 | In-stock |
| 100mg | $550 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-109587 |
| M.Wt: | 392.51 |
| Formula: | C25H29FN2O |
| Purity: | >98 % |
| Solubility: | DMSO : 31 mg/mL (ultrasonic;warming) |
BM635 is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 has an MIC50 of 0.12 μM against M. tuberculosis H37Rv. IC50 & Target: MIC50: 0.12 μM (M. tuberculosis H37Rv)[1] In Vivo: BM635 has potent MIC (0.12 µM), Tox50:MIC ratio of >100, and good microsomal stability in mice (1.4 mL/min/g). When tested in an acute murine infection model at multiple doses, BM635 exhibits potent anti-tubercular activity, with an ED99 of 49 mg/Kg (IC95%: 43–54 mg/Kg)[1]. The half-life in vivo of BM635 is 1h, allowing a reasonable maximum concentration (Cmax=1.62 μM) and a moderate bioavailability (46%). Its poor aqueous solubility together with its high lipophilicity leads to low exposure in vivo[2].
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