UNC2250
CAS No. : 1493694-70-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $77 | In-stock |
| 10mg | $132 | In-stock |
| 25mg | $290 | In-stock |
| 50mg | $484 | In-stock |
| 100mg | $814 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-15797 |
| M.Wt: | 440.58 |
| Formula: | C24H36N6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 10 mg/mL;0.1 M HCL : 12.5 mg/mL (ultrasonic;adjust pH to 3 with HCl) |
UNC2250 is a potent and selective Mer inhibitor with an IC50 of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3.
IC50 & Target: IC50: 1.7 nM (Mer)[1]
In Vitro: UNC2250 (5-500 nM; 1 hour) inhibits Mer phosphorylation in 697 B-ALL cells with an IC50 value of 9.8 nM[1].
UNC2250 efficiently inhibits ligand-dependent phosphorylation of a chimeric protein consisting of the extracellular and transmembrane domains of the epidermal growth factor (EGF) receptor and the intracellular tyrosine kinase domain of Mer[1].
UNC2250 incubation inhibits colony formation in soft agar cultures of the BT-12 rhabdoid tumor and the Colo699 NSCLC cell lines[1] .
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