(Z)-RG-13022
CAS No. : 149286-90-8
(Synonyms: (Z)-Tyrphostin RG13022)
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| Cat. No. : | HY-117523 |
| M.Wt: | 266.29 |
| Formula: | C16H14N2O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
(Z)-RG-13022 is a tyrosine kinase (TK) inhibitor, which inhibits preferentially the TK activity of the EGF receptor and inhibits EGF-stimulated growth of cultured cells. (Z)-RG-13022 exerts an IC50 of 11 μM for DNA synthesis in the HN5 cells, which is 3 times more potent than (E)-RG-13022 (IC50=38 μM). (Z)-RG-13022 can be used for research of breast cancer cells[1][2].
In Vitro:(Z)-RG-13022 (1-100 μM, 24 h) inhibits the DNA synthesis in the HN5 cells dose-dependently and doesn't affect the cell viability[2].
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