RB-042
CAS No. : 1491909-40-0
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| Cat. No. : | HY-124368 |
| M.Wt: | 373.63 |
| Formula: | C25H43NO |
| Purity: | >98 % |
| Solubility: |
RB-042 is a SK1 and SK2 inhibitor with IC50 values of 5.3 μM and 5.0 μM, respectively. RB-042 is applicable to the research of inflammatory diseases[1][2].
In Vitro:RB-042 is an equipotent inhibitor of sphingosine kinase 1 and sphingosine kinase 2, with an IC50 value of 5.3 μM against SK1 and 5.0 μM against SK2[1].
RB-042 binds to the catalytic site of sphingosine kinase 1 via polar interactions with residues D178, D81, and L268[1].
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