CGP55845 (hydrochloride)
CAS No. : 149184-22-5
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| 10mg | $460 | In-stock |
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| Cat. No. : | HY-103516 |
| M.Wt: | 438.71 |
| Formula: | C18H23Cl3NO3P |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CGP55845 hydrochloride is a potent and selective GABAB receptor antagonist with an IC50 of 6 nM. CGP55845 hydrochloride can be used for neurological research[1][2]. In Vitro: In the mouse visual cortex, CGP 55845 hydrochloride (1 μM) increases the frequency of spontaneous Ca2+ transients and spontaneous and miniature IPSCs (mIPSCs) but does not affect mIPSC amplitudes or kinetics. CGP55845 hydrochloride significantly increases evoked IPSC (eIPSC) amplitudes and decreases the paired-pulse ratio (PPR)[3]. In Vivo: CGP55845 hydrochloride (i.p.; once; 0.5 mg/kg) treatment increases the number of PSD95 positive puncta as well as density and maturation of dendritic spines in the perirhinal cortex (PRC), and restores novel object recognition (NOR) memory in Cdkl5 KO mice[1].
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