AG 556
CAS No. : 149092-35-3
(Synonyms: Tyrphostin AG 556)
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| Cat. No. : | HY-119924 |
| M.Wt: | 336.38 |
| Formula: | C20H20N2O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
AG 556 (Tyrphostin AG 556) is a highly selective EGFR kinase inhibitor. AG 556 reversibly inhibits the human ether á-go-go gene potassium channels (hEAG1 or Kv10.1) with IC50s of 6.1, 6.7 and 5.8 μM for inhibiting WT, Y376A and Y479A hEAG1 channels[1].
In Vitro: AG 556 is an EGFR substrate-site competitor. AG 556 (1-10 µM) inhibits GB1B cells and AC1B cells growth in a time and dose dependent manner[2].
AG 556 (10 and 50 μM) is effective in inhibiting the phosphorylation of p42MAPK/ERK2 and p44MAPK/ERK1[3].
In Vivo: Inhibition of EGFR kinase by AG 556 (5 mg/kg; i.p.) exerts an antiarrhythmic effect in the rat model of reperfusion-induced arrhythmias[4].
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