PPADS
CAS No. : 149017-66-3
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| Cat. No. : | HY-108960 |
| M.Wt: | 511.38 |
| Formula: | C14H14N3O12PS2 |
| Purity: | >98 % |
| Solubility: |
PPADS is a P2 receptor antagonist, with IC50s of 68 nM (P2X1) and 214 nM (P2X3). PPADS acts as an ATP (nucleotide) mimetic and competes with ATP for its binding site on P2 receptors. PPADS is also a reversible competitive antagonist of the NAADP receptor. PPADS reverses nociceptive hypersensitivity and reduces the increased NO/NOS system and IL-1β in both peripheral and central steps of nervous system[1][2][3].
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