Patulin
CAS No. : 149-29-1
(Synonyms: Terinin)
| Size | Price | Stock |
|---|---|---|
| 1mg | $70 | In-stock |
| 5mg | $200 | In-stock |
| 10mg | $380 | In-stock |
| 25mg | $760 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-N6779 |
| M.Wt: | 154.12 |
| Formula: | C7H6O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 50 mg/mL (ultrasonic;warming) |
Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage[1][2][3][4].
In Vitro:Patulin (2 μM, 6-24 h) induces LMP and reduces Cathepsin B release in an autophagy-dependent manner in HepG2 cells[3].
Patulin (2 μM, 6-24 h) increases cytochrome c protein level and leads apoptosis induction in an autophagy-dependent manner in HepG2 cells[3].
Patulin (2 μM, 6-24 h) impairs mitophagy in HepG2 cells[3].
In Vivo:Patulin (1-3.75 mg/kg, i.p., once time) induces DNA damage in the brain, liver and kidneys in a dose-dependent manner in CF-1 mice[4].
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