Guanylyl Imidodiphosphate (trisodium)
CAS No. : 148892-91-5
(Synonyms: Guanosine 5'-[β,γ-imido]triphosphate (trisodium))
| Size | Price | Stock |
|---|---|---|
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| 10mg | $340 | In-stock |
| 25mg | $720 | In-stock |
| 50mg | $1225 | In-stock |
| 100mg | $2100 | In-stock |
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| Cat. No. : | HY-100767 |
| M.Wt: | 591.16 |
| Formula: | C10H17N6Na3O13P3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Guanylyl Imidodiphosphate (Guanosine 5'-[β,γ-imido]triphosphate) trisodium is a non-hydrolysable GTP analogue, an activator of ADP-ribosylation factor (ARF) and a potent stimulator of adenylate cyclase. Imidodiphosphate trisodium can be used in protein synthesis studies[1][2][3].
In Vitro: Guanylyl Imidodiphosphate trisodium (GppNHp) (100 μM) induces the secretion of dense granules from permeabilized platelets in response to calcium ion stimulation, and GTP-Ral enhances the calcium sensitivity of permeabilized platelet dense granule secretion which is inhibited by Sec5-RBD[1].
Guanylyl Imidodiphosphate trisodium (GppNHp) (0.017-333 μM) causes a significant reduction in the lag time required to stimulate adenylate cyclase activity[3].
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