Ivabradine (hydrochloride)


CAS No. : 148849-67-6

148849-67-6
Price and Availability of CAS No. : 148849-67-6
Size Price Stock
5mg $35 In-stock
10mg $55 In-stock
25mg $110 In-stock
50mg $190 In-stock
100mg $350 In-stock
200mg $650 In-stock
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Cat. No. : HY-B0162A
M.Wt: 505.05
Formula: C27H37ClN2O5
Purity: >98 %
Solubility: DMSO : 25 mg/mL (ultrasonic);H2O : 50 mg/mL (ultrasonic)
Introduction of 148849-67-6 :

Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine hydrochloride reduces dose-dependently heart rate without modification of blood pressure. Ivabradine hydrochloride shows anticonvulsant, anti-ischaemic and anti-anginal activity[1][2][3][4]. In Vivo:Ivabradine hydrochloride (1, 10, 20 mg/kg; i.p.) shows anticonvulsant and neuroprotective action in mice[3].
Ivabradine hydrochloride (5, 10, 20 mg/kg;p.o.; daily for 1 weeks) lowers heart rate in mice with enhanced sympathoadrenergic activities[4].

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