Adomeglivant
CAS No. : 1488363-78-5
(Synonyms: LY2409021)
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $250 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $750 | In-stock |
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| Cat. No. : | HY-19904 |
| M.Wt: | 555.63 |
| Formula: | C32H36F3NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Adomeglivant (LY2409021) is a potent, selective glucagon receptor (GluR) allosteric antagonist. Adomeglivant is widely used in the research for type 2 diabetes mellitus[1][2][3].
IC50 & Target: GluR[1][2]
In Vitro: Adomeglivant dose-dependently blocks glucagon-induced the raise levels of cAMP in HEK293-GluR cells[2].
Adomeglivant fails to block cAMP-elevating actions of adenosine[2].
Adomeglivant exhibits high selectivity for family B GPCRs, and specifically interacts with a conserved binding motif within the GluR, GLP-1R, and GIP-R[2].
In Vivo: Adomeglivant (5 mg/kg; i.p.) completely abolishes the hyperglycaemic action of CNO (clozapine-N-oxide) in Avpires-Cre+ mice. (CNO is a specific, pharmacologically inert agonist for hM3Dq-induced membrane depolarisation and increased the firing rate in hM3Dq-expressing arginine-vasopressin (AVP) neurons.)[3]
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