EGCG Octaacetate

EGCG Octaacetate (AcEGCG) is a proagent of Green tea epigallocatechin-3-gallate (EGCG). EGCG Octaacetate decreases the proinflammatory mediator levels by down-regulating of PI3K/Akt/NFκB phosphorylation and p65 acetylation. EGCG octaacetate is the potential antibacterial compound for gram-positive bacteria (GPB) and gram-negative bacteria (GNB). EGCG Octaacetate exhibits antioxidant, anti-angiogenesis, anti-inflammatory and antitumor activities^[1][2][3]. In Vitro:EGCG Octaacetate generates H₂O₂, destroys the integrity of bacterial cell membranes, leading to leakage of cell contents and cell death. EGCG Octaacetate inhibits Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Yersinia enterocolitica with MICs of 100 μg/mL, 150 μg/mL, 250 μg/mL and 280 μg/mL, respectively^[2].
EGCG Octaacetate (0-40 μM, 24 h) inhibits the growth of esophageal squamous carcinoma cell KYSE150 and colon cancer cell HCT116, reduces NO production and arachidonic acid release in LPS (HY-D1056)-stimulated RAW264.7^[4].
In Vivo:EGCG Octaacetate (0.017%-0.085% in feed supplementation, po for 14 days) ameliorates DSS (HY-116282C)-induced colitis and AOM (HY-111375)+DSS-induced colon cancer in mouse model^[3].