GR127935
CAS No. : 148672-13-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $200 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-123869 |
| M.Wt: | 497.59 |
| Formula: | C29H31N5O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
GR127935 is a potent and orally active 5-HT1D and 5-HT1B receptor antagonist with pKis of 8.5 for both isoforms. GR127935 hydrochloride has 100-fold selectivity for 5-HT1B/1D receptors over 5-HT1A, 5-HT2A, and 5-HT2C receptors. GR127935 can be used in neurological disease research[1][2].
In Vitro:GR127935 (1-10 nM) potently antagonizes Sumatriptan (HY-B0121B)-induced contractions in dog isolated basilar artery[1].
GR127935 (1-300 nM) blocks prejunctional 5-HT1 receptors on sympathetic nerve terminals in dog saphenous vein[1].
In Vivo:GR127935 (10-300 μg/kg, p.o., once) dose-dependently inhibits GR56764-induced contralateral rotations in guinea-pigs, with ID50 of 28 μg/kg[1].
GR127935 (0.005-0.5 ng/mouse, intra-CA1, 5 min before training) impairs memory acquisition in adult male NMRI mice[1].
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