GR 125743
CAS No. : 148547-33-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $300 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $750 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-121392 |
| M.Wt: | 416.52 |
| Formula: | C25H28N4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
GR 125743 is a selective 5-HT1B/1D receptor antagonist, with pKis of 8.85 and 8.31 for wild-type h5-HT1B and wild-type h5-HT1D, respectively. GR 125743 is used for the research of Parkinson's disease and cardiovascular diseases[1][2].
IC50 & Target: pKi: 8.85 (wt h5-HT1B), 8.31 (wt h5-HT1D)[1]
In Vitro: GR 125743 has a Kd of 0.61 nM for h5-HT1B[1].
In Vivo: GR 125743 (0.3 mg/kg; i.p.) produces significant decreases in extracellular 5-HT in the frontal cortex of the conscious guinea pig[2].
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