Fradafiban
CAS No. : 148396-36-5
(Synonyms: BIBU-52)
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| Cat. No. : | HY-101720 |
| M.Wt: | 367.40 |
| Formula: | C20H21N3O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 180 mg/mL (ultrasonic) |
Fradafiban is a nonpeptide platelet glycoprotein IIb/IIIa antagonist, which binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. IC50 & Target: Kd: 148 nM (human platelet GP IIb/IIIa complex)[1] In Vitro: Fradafiban is a nonpeptide mimetic of the arginine-glycine-aspartic acid recognition sequence. Fradafiban binds with high affinity and selectivity to the human platelet GP IIb/IIIa complex and potently inhibits human platelet aggregation in vitro. Fradafiban reversibly binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM[1]. In Vivo: Fradafiban has only very limited oral activity probably due to its high polarity and thus poor absorption after oral ingestion[1].
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