Doripenem
CAS No. : 148016-81-3
(Synonyms: S 4661)
| Size | Price | Stock |
|---|---|---|
| 5mg | $35 | In-stock |
| 10mg | $55 | In-stock |
| 25mg | $90 | In-stock |
| 50mg | $150 | In-stock |
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| Cat. No. : | HY-B0187 |
| M.Wt: | 420.50 |
| Formula: | C15H24N4O6S2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 200 mg/mL |
Doripenem (S 4661), a 1β-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria[1][2].
In Vivo:Doripenem (S 4661; MIC range of 2 to 16 μg/ml; Subcutaneous; 1-h and 4-h infusion; 0.2 ml injections) monohydrate demonstrates antibacterial killing for P. aeruginosa[1].
Doripenem (10, 50, 150 mg/kg; 0.2-ml volumes; subcutaneously 2 h) has a T1/2 of 0.41 hours, a CL of 673.9 mL/h•kg for mice with 10 mg/kg[1].
Pharmacokinetic Parameters of Doripenem in mice[1].
| SC (10 mg/kg) | SC (50 mg/kg) | SC (150 mg/kg) | |
| Tmax (h) | 0.25 | 0.38 | 0.22 |
| Cmax (μg/mL) | 16.3 | 59.7 | 194.4 |
| AUC0-24 (ng·h /mL) | 13.5 | 62.4 | 168 |
| t1/2 (h) | 0.41 | 0.34 | 0.44 |
| CL (mL/h/kg) | 673.9 | 783.3 | 850.5 |
| V (mL/kg) | 400.7 | 384.7 | 545.8 |
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