8-Hydroxyquinoline

8-Hydroxyquinoline (8-Quinolinol) is a lipophilic metal chelator that can be used as a fungicide .8-Hydroxyquinoline shows the MIC range of 27.56-55.11 μM (4-8 μg/mL) against the clinical isolates of Neisseria gonorrhoeae. 8-Hydroxyquinoline can bind to copper form complexes and transport copper into cells. 8-Hydroxyquinoline increases in the number of micronucleated polychromatic erythrocytes and can also make hair depigmented in mice^{[1][2][3][4][5]}. In Vitro:8-Hydroxyquinoline (8HQ) (Compd 1) shows cytotoxicity in MRC-5 cells with an IC₅₀ of 6.27 μM^[1].
8-Hydroxyquinoline (8-OHQ) (Compd 1) (mixture of CuCl₂ at 10.0 μM, 1 hour) binds to copper and form complexes can facilitate transport of copper into human breast cancer DCIS cells^[2].
8-Hydroxyquinoline (mixture of CuCl₂ at 1-20 μM; 1 or 8 hour) binds to copper and form complexes induces cell death with a time and dose-dependent manner in DCIS cells^[2].
8-Hydroxyquinoline (mixture of CuCl₂ at 1-5 μM, 2-12 hour) inhibits proteasomal chymotrypsin-like activity^[2].
8-Hydroxyquinoline (0-100 μM, 30 min) acts to inhibit inflammation through inhibition of NO production and iNOS expression through blockade of C/EBPb DNA-binding activity and NF-jB activation in Raw 264.7 cells^[3].
In Vivo:8-Hydroxyquinoline (HOQ) (25-100 mg/kg, i.p.,single dose) results in a significant dose-related increase in the number of micronucleated polychromatic erythrocytes (MPCE) in CD1 mice^[4].
8-Hydroxyquinoline (8-HQ) (0.3%, skin administration, 4 times weekly) causes depigmented hair to grow in patterns which change with time in mice^[5].