Santacruzamate A
CAS No. : 1477949-42-0
(Synonyms: CAY-10683)
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $65 | In-stock |
| 25mg | $150 | In-stock |
| 50mg | $250 | In-stock |
| 100mg | $375 | In-stock |
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| Cat. No. : | HY-N0931 |
| M.Wt: | 278.35 |
| Formula: | C15H22N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Santacruzamate A (CAY-10683, STA) is a potent and selective HDAC2 inhibitor with an IC50 of 119 pM. STA also exerts neuroprotective property against amyloid-β protein fragment 25–35. STA can be used for cancer and neurological disease research[1][2].
In Vitro:Santacruzamate A (0.016-50 μM, 28 h) attenuates amyloid-β protein fragment 25–35-induced apoptosis and reverses Aβ25–35-induced unfolded protein response and endoplasmic reticulum stress in PC12 and SH-SY5Y. 2 μM STA shows the strongest protective effects[2].
Santacruzamate A (0.016-50 μM, 12 h) up-regulates KDEL receptor (KDELR) expression, reinforces ER luminal retention of chaperones, and enhances the binding of PERK to GRP78, inhibiting the amyloid-β protein fragment 25–35-induced mitochondrial fission and apoptosis pathways in PC12[2].
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