Suprafenacine
CAS No. : 1477482-50-0
(Synonyms: SRF)
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| 5mg | $255 | In-stock |
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| Cat. No. : | HY-118748 |
| M.Wt: | 282.34 |
| Formula: | C16H18N4O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Suprafenacine is a cell permeable, tubulin-destabilizing molecule which bind microtubules at the colchicine-binding site and inhibit polymerization. Suprafenacine can induce G2/M cell cycle arrest and apoptosis, and can be used for cancer research[1].
In Vitro:Suprafenacine (10 μM, 24 h) causes a complete collapse of all the cells at the G1 phase and increases the G2/M population of the Hela cells while 7 h of pretreatment induces rapid apoptosis in proliferating Hela cells[1].
In Vivo:Suprafenacine (20 mg/kg, i.p., every 3 days for 9 days) suppresses 40% of tumor mass in HCT15 tumor bearing SCID mice compared with control mice[1].
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