Win 18446
CAS No. : 1477-57-2
| Size | Price | Stock |
|---|---|---|
| 50mg | $60 | In-stock |
| 100mg | $90 | In-stock |
| 500mg | $235 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
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| Cat. No. : | HY-W011094 |
| M.Wt: | 366.11 |
| Formula: | C12H20Cl4N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC50 of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid (HY-14649) biosynthesis from Retinol (HY-B1342) within the testes[1][2]. In Vitro: WIN 18446 (1 μM, 24 h) is able to suppress Stra8 expression in whole-testes cultures that contained both germ and somatic cells[2]. In Vivo: Win 18446 (200 mg/kg, Orally for 4, 8, and 16 weeks) significantly reduces intratesticular concentrations of retinoic acid, severely impaired spermatogenesis, and caused infertility[1].
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