(+)-EMD 57033
CAS No. : 147527-31-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $385 | In-stock |
| 5mg | $910 | In-stock |
| 10mg | $1250 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-106844A |
| M.Wt: | 425.50 |
| Formula: | C22H23N3O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
(+)-EMD 57033 is a cardiac troponin C (cTnC) activator, is a dominant Ca2+ sensitizer. (+)-EMD 57033 binds the cardiac/slow skeletal troponin C isoform and exerts myocardial contractile promotion function[1].
IC50 & Target: Cardiac troponin C (cTnC)[1]
In Vitro: (+)-EMD 57033 (30 μM) recovers the activation and sensitivity of Ca2+ in pig single muscle fibres and reduces VIDD (ventilator-induced diaphragm muscle fibre dysfunction) of [2].
(+)-EMD 57033 (5.0-5.8 μM; 10-15 min) significantly increases the coronary blood flow and myocardial V?o2 (O2?consumption) in both 100 bpm and 150 bpm heart rates of rabbit heart, with a [Ca2+]0 concentration-dependent manner ([Ca2+]0=1.0 or 2.5 mM)[3].
(+)-EMD 57033 (5.0-5.8 μM; 10-15 min) increases left ventricular?(LV) end-diastolic pressure and prolongs relaxation[3].
In Vivo: (+)-EMD 57033 (0.4 or 0.8 mg/kg/min; i.v.drip; over than 20 min) enhances contractility and achieves Ca2+ sensitization in intact failing hearts at substantial energetic savings and without compromise of diastolic function in dogs[4].
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