LY288513
CAS No. : 147523-65-7
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| Cat. No. : | HY-103357 |
| M.Wt: | 436.30 |
| Formula: | C22H18BrN3O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
LY288513 is a selective non-peptide CCK-B receptor antagonist with an IC50 value of 16 nM. LY288513 produces an anxiolytic-like action in mice[1][2][3].
IC50 & Target: IC50: 16 nM (CCK-B receptor)[1]
In Vitro: LY288513 (10 nM; 2 days) suppresses the effects of CCK-8 on CD4+ T cell subset-specific transcription factors[2].
In Vivo: LY288513 (3, 10 mg/kg, i.p.; 10, 30 mg/kg, p.o.) produces an anxiolytic-like action in mice[3].
LY288513 (1000 mg/kg, p.o.) potentiates the effects of a CNS depressant, slightly lowered body temperature, and had modest sedative effects only at the highest dose examined[3].
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