GSK2981278
CAS No. : 1474110-21-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $30 | In-stock |
| 5mg | $65 | In-stock |
| 10mg | $100 | In-stock |
| 25mg | $185 | In-stock |
| 50mg | $275 | In-stock |
| 100mg | $420 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-19770 |
| M.Wt: | 461.61 |
| Formula: | C25H35NO5S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
GSK2981278 is a potent and selective RORγ inverse agonist. GSK2981278 inhibits activation of the il17 promoter and interferes RORγ-DNA binding[1].
IC50 & Target: RORγ[1]
In Vitro: GSK2981278 markedly and potently inhibits IL-17A and IL-22 protein secretion in a concentration dependent manner (IC50 = 3.2 nM) during 5 days of culture under Th17 skewing conditions[1].
GSK2981278 (0.3, 1, 3, 10, 30, 100, 300, 1000 pM; 5 day) potently and selectively inhibits IL-17 and IL-22 levels. Culture in the presence of ≥3 nM GSK2981278 led to a near-complete inhibition of IL-17A protein secretion[1].
In Vivo: GSK2981278 (1% in ointment; topically; for three days) reduces skin redness and scaling, as well as decreased hyperplasia, as evidenced by a 23% reduction in epidermal thickness. GSK2981278 attenuates inflammation in a mouse model of psoriasis[1].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- GSK2981278
- Cat. No.:
- HY-19770
- Quantity:
Your information is safe with us.