U 93385
CAS No. : 147145-16-2
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| Cat. No. : | HY-106928 |
| M.Wt: | 258.36 |
| Formula: | C16H22N2O |
| Purity: | >98 % |
| Solubility: |
U93385 is a 5-HT₁A receptor agonist. U93385 exhibits no significant α₂ adrenergic, D₂ dopamine, or other receptor activities. U93385 has a heart rate regulating effect, stimulating the vagus nerve to induce bradycardia. U93385 can be used to study the 5-HT₁A receptor-mediated vagal nerve tolerance mechanism[1]. In Vivo:U 93385 (0.01-3 mg/kg, i.v., single dose, cumulative administration or intravenous infusion) results in a 20-30% decrease in heart at administration of a single dose but fails to lower heart rate in the spinal cat by cumulative dosing and infusion[1].
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