Rosuvastatin (Calcium)
CAS No. : 147098-20-2
(Synonyms: Rosuvastatin hemicalcium; ZD 4522 Calcium)
| Size | Price | Stock |
|---|---|---|
| 5mg | $25 | In-stock |
| 10mg | $30 | In-stock |
| 50mg | $60 | In-stock |
| 100mg | $104 | In-stock |
| 200mg | $158 | In-stock |
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| Cat. No. : | HY-17504 |
| M.Wt: | 500.57 |
| Formula: | C22H27Ca0.5FN3O6S |
| Purity: | >98 % |
| Solubility: | H2O : 1 mg/mL (ultrasonic);DMSO : 25 mg/mL (ultrasonic) |
Rosuvastatin Calcium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Calcium potently blocks hERG current with an IC50 of 195 nM[2]. Rosuvastatin Calcium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Calcium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels[1][2][3].
IC50 & Target: IC50: 11 nM (HMG-CoA), 195 nM (hERG)[1][2]
In Vivo: Rosuvastatin Calcium (10 mg/kg, intraperitoneal) prolonges QTc in conscious and unrestraines guinea pigs from 201±1 to 210±2 ms[2].
Rosuvastatin (20 mg/kg/day, for 2 weeks) significantly reduces very low-density lipoproteins Calcium (VLDL) in diabetes mellitus rats induced by Streptozocin[4].
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