Rosuvastatin (Sodium)
CAS No. : 147098-18-8
(Synonyms: ZD 4522 (Sodium); X-Plended (Sodium); Crestor (Sodium))
| Size | Price | Stock |
|---|---|---|
| 5mg | $38 | In-stock |
| 10mg | $60 | In-stock |
| 50mg | $92 | In-stock |
| 100mg | $119 | In-stock |
| 200mg | $158 | In-stock |
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| Cat. No. : | HY-17504B |
| M.Wt: | 503.52 |
| Formula: | C22H27FN3NaO6S |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC50 of 195 nM[2]. Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels[1][2][3].
IC50 & Target: IC50: 11 nM (HMG-CoA), 195 nM (hERG)[1][2]
In Vivo: Rosuvastatin Sodium (10 mg/kg, intraperitoneal) prolonges QTc in conscious and unrestraines guinea pigs from 201±1 to 210±2 ms[2].
Rosuvastatin (20 mg/kg/day, for 2 weeks) significantly reduces very low-density lipoproteins Sodium (VLDL) in diabetes mellitus rats induced by Streptozocin[4].
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