Diphenhydramine (hydrochloride)
CAS No. : 147-24-0
| Size | Price | Stock |
|---|---|---|
| 25g | $20 | In-stock |
| 100g | $45 | In-stock |
| 500g | $145 | In-stock |
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| Cat. No. : | HY-B0303A |
| M.Wt: | 291.82 |
| Formula: | C17H22ClNO |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 100 mg/mL (ultrasonic) |
Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB)[1][2].
In Vitro: Diphenhydramine hydrochloride inhibits Cisplatin (HY-17394)-induced cell death in kidney proximal tubular cells (HK-2 and LLC-PK1 cells)[3].
Diphenhydramine (0.2-1 mM, 24 h) hydrochloride inhibits cell viability in CCRF-CEM and Jurkat cells[4].
Diphenhydramine (0.5 and 1 mM, 24 h) hydrochloride induces apoptosis in CCRF-CEM and Jurkat cells[4].
Diphenhydramine (0-10 μg/mL, 24 or 48 h) hydrochloride increases the expression of Bad and Bax, and decreases BCL-2 level in PANC-1 cells[5].
In Vivo: Diphenhydramine (20 mg/kg) hydrochloride inhibits Cisplatin (HY-17394)-induced kidney toxicity in mice[3].
Diphenhydramine (3-30 mg/kg, i.m., 5 minutes prior to a s.c. of 25 mg/kg Dichlorvos) hydrochloride reduces mortality in rats with acute, severe dichlorvos exposure[6].
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